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KMID : 0370219850290020055
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Yakhak Hoeji
1985 Volume.29 No. 2 p.55 ~ p.61
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Effect of Dietary Fat on the Immunotoxicity of Chloramphenicol
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안영근/Ahn YK
김주영/Kim JY
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Abstract
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The effect of dietary fat on the immunotoxicity of chloramphenicol was investigated in mice, sensitized and challenged with sheep red blood cells. Chloramphenicol suppressed more cell-mediated immunity than humoral immunity. The saturated fat diet elevated humoral and cell-mediated immunotoxicity, whereas the unsaturated fat diet decreased humoral immunotoxicity, but elevated cell-mediated immunotoxicity of chloramphenicol. Especially, the normal diet in saturated and unsaturated fat restored immunosuppressive effect of chloramphenicol compared to the saturated fat diet and the unsaturated fat diet.
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